Description

Propargyl-Peg3-Acid CAS NO 1347760-82-0 is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring a terminal carboxylic acid and a propargyl group. This molecular structure is critical for facilitating controlled bioconjugation and click chemistry reactions, enabling the precise modification of biomolecules, polymers, and surfaces. It is an essential building block for researchers and manufacturers in the fields of biopharmaceutical development, advanced material science, and diagnostic probe synthesis.

Application

• Bioconjugation and ADC Development: Used as a key linker for attaching cytotoxic drugs to antibodies in Antibody-Drug Conjugate (ADC) therapeutics, leveraging its click-ready propargyl group for site-specific coupling.
• PEGylation Reagent: Serves as a heterobifunctional PEG spacer to modify peptides, proteins, and oligonucleotides, improving solubility, stability, and pharmacokinetic profiles.
• Polymer and Material Science: Acts as a functional monomer or cross-linker in the synthesis of smart hydrogels, functionalized surfaces, and biocompatible polymers via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Diagnostic Probe Synthesis: Facilitates the labeling of biomarkers, fluorescent dyes, or contrast agents for in vitro and in vivo imaging applications.
• Drug Delivery Systems: Incorporated into nanocarriers and micelles to create targeted delivery platforms with cleavable or stable linkages.
• Chemical Biology Tool: Enables the study of protein-protein interactions, cellular trafficking, and post-translational modifications through bioorthogonal labeling strategies.

Basic Information

Product Name	Propargyl-Peg3-Acid
CAS No.	1347760-82-0
Molecular Formula	C12H20O6
Molecular Weight	260.28 g/mol
Synonyms	Propargyl-PEG3-acid; 3,6,9-Trioxa-12-dodecynoic acid, 11-yn-1-oic acid; 17-Prop-2-yn-1-yl-3,6,9,12,15-pentaoxaheptadecan-1-oic acid; Propargyl-PEG3-COOH; Propargyl-O-CH2CH2-O-CH2CH2-O-CH2CH2-COOH; Alkyne-PEG3-acid; 5-((Prop-2-yn-1-yloxy)methyl)-5-oxopentanoic acid (linear form representation); Propargyl tetraethylene glycol carboxylic acid
EINECS	Contact for details

Quality Control

Our Propargyl-Peg3-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for critical research and cGMP-grade applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, consider sealing under argon or nitrogen.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical: 97-99%)
Water Content (KF)	≤ 1.0%
Acid Value (Titration)	210 - 230 mg KOH/g

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.