Description

Ho-Peg6-Ch2Ch2Cooh CAS NO 1347750-85-9 is a functionalized polyethylene glycol (PEG) derivative featuring a terminal carboxylic acid group, designed as a versatile heterobifunctional linker for bioconjugation and material science. This compound matters because it provides a reliable, water-soluble spacer arm that enables the stable attachment of biomolecules, drugs, or surfaces via its reactive carboxyl end while offering the biocompatibility and stealth properties of a PEG chain. It is essential for researchers and manufacturers in the pharmaceutical, diagnostic, and advanced materials sectors who require precise and stable conjugation chemistries for developing targeted therapeutics, biosensors, and functionalized nanomaterials.

Application

• Bioconjugation Reagent: Used to covalently link peptides, proteins, or antibodies to nanoparticles, surfaces, or other molecules via amide bond formation.
• Drug Delivery Systems: Serves as a key component in the synthesis of PEGylated drug conjugates, enhancing solubility, circulation time, and targeting efficacy.
• Diagnostic Assay Development: Employed to functionalize sensor surfaces or label biomolecules for ELISA, lateral flow assays, and other diagnostic platforms.
• Hydrogel and Biomaterial Synthesis: Acts as a crosslinker or functional monomer to introduce carboxylic acid groups into polymer networks for tissue engineering scaffolds.
• Surface Modification: Used to create hydrophilic, non-fouling coatings on medical devices, implants, and chromatography media.
• Click Chemistry & Organic Synthesis: Provides a PEG-acid building block for further derivatization in combinatorial chemistry and the synthesis of complex molecular architectures.

Basic Information

Product Name	Ho-Peg6-Ch2Ch2Cooh
CAS No.	1347750-85-9
Molecular Formula	C23H44O11
Molecular Weight	496.59 g/mol
Synonyms	HO-PEG6-COOH; 17-Carboxy-3,6,9,12,15-pentaoxaheptadecan-1-ol; 2-[2-[2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic Acid; Carboxy-PEG6-alcohol; Acetic acid, 2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]-; Heterobifunctional PEG, Acid-PEG6-OH; PEG Acid, 6-ethylene oxide units; α-Hydroxy-ω-carboxy hexaethylene glycol
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical applications. Each batch is characterized by NMR, HPLC, and mass spectrometry to confirm identity, purity, and functional group integrity. Certificates of Analysis (COA) detailing lot-specific results are available upon request. We adhere to cGMP principles where applicable to support our customers' development and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent hydrolysis of the active ester or degradation. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Acid Value (Titration)	105 - 120 mg KOH/g

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.