Description

Maleimide-NH-PEG2-CH2CH2COOH-PFP Ester is a specialized heterobifunctional crosslinking reagent designed for precise bioconjugation and the development of advanced drug delivery systems. Its core value lies in combining a maleimide group for thiol-specific coupling with a pentafluorophenyl (PFP) ester for efficient amine modification, connected by a hydrophilic PEG spacer to enhance solubility and reduce steric hindrance. This compound is essential for researchers and manufacturers in biopharmaceutical development, antibody-drug conjugate (ADC) synthesis, and diagnostic assay kit production, where controlled and stable linker chemistry is paramount.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: For the site-specific conjugation of cytotoxic payloads to monoclonal antibodies via thiol or amine groups.
• Protein and Peptide Labeling: Enables the attachment of fluorophores, biotin, or other probes to biomolecules for imaging and detection.
• Surface Functionalization: Used to modify nanoparticles, biosensors, or chromatography resins with bioactive ligands.
• Polymer-Protein Hybrids: Facilitates the creation of PEGylated therapeutics to improve pharmacokinetic profiles.
• Diagnostic Reagent Synthesis: A key building block in the manufacture of components for immunoassays and lateral flow tests.
• Hydrogel Formation: Acts as a crosslinker in the synthesis of biomaterial scaffolds for tissue engineering.

Basic Information

Product Name	Maleimide-NH-PEG2-CH2CH2COOH-PFP Ester
CAS No.	1347750-81-5
Molecular Formula	C₂₀H₂₁F₅N₂O₈
Molecular Weight	512.39 g/mol
Synonyms	Maleimide-PEG2-PFP Ester; 3-Maleimidopropanoic acid PFP ester, PEGylated; PFP-PEG2-Maleimide; 2,3,5,6-Tetrafluorophenyl 3-(2-{2-[(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methoxy]ethoxy}ethoxy)-3-oxopropyl carbonate; Maleimide-PEG2-acid-PFP ester; NHS-PEG2-Maleimide analog (PFP ester); Heterobifunctional PEG linker, Maleimide and PFP ester terminated; Pentafluorophenyl 3-(2-{2-[(2,5-dioxopyrrol-1-yl)methoxy]ethoxy}ethoxy)propanoate
EINECS	Contact for details

Quality Control

Our Maleimide-NH-PEG2-CH2CH2COOH-PFP Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.