Description

Thiol-Dpeg5-Azido CAS NO 1347750-79-1 is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a thiol group at one terminus and an azido group at the other, separated by a pentaethylene glycol spacer. This compound is essential for creating stable, site-specific bioconjugates and functionalized materials via orthogonal click chemistry reactions. It is primarily used by researchers and manufacturers in the fields of bioconjugation, pharmaceutical development, and advanced material science.

Application

• Bioconjugation and Protein Modification: Site-specific coupling of peptides, proteins, or antibodies via thiol-maleimide or thiol-haloacetyl chemistry, followed by azide-alkyne cycloaddition for labeling or immobilization.
• PEGylation of Therapeutics: Introduction of a hydrophilic PEG spacer to improve the solubility, stability, and pharmacokinetic profiles of drug molecules or nanoparticles.
• Surface Functionalization: Creating functional monolayers on gold or other surfaces through the thiol group for subsequent attachment of azide-reactive probes, ligands, or biomolecules.
• Hydrogel and Polymer Network Formation: Serving as a crosslinking agent in the synthesis of smart hydrogels or functional polymers using dual-click chemistry strategies.
• Diagnostic Reagent Synthesis: Fabrication of diagnostic conjugates, such as antibody-fluorophore or antibody-enzyme complexes, for assays and imaging.
• Drug Delivery System Development: Constructing targeted drug delivery carriers by linking targeting moieties (via azide) to drug-loaded nanoparticles or liposomes (via thiol).

Basic Information

Product Name	Thiol-Dpeg5-Azido
CAS No.	1347750-79-1
Molecular Formula	C19H39N3O6S
Molecular Weight	437.6 g/mol
Synonyms	Azido-PEG5-Thiol; 1-Azido-3,6,9,12,15-pentaoxaheptadecan-17-thiol; N3-PEG5-SH; HS-PEG5-N3; α-Azido-ω-thiol pentaethylene glycol; Heterobifunctional PEG crosslinker, N3-PEG5-SH; 17-Mercapto-3,6,9,12,15-pentaoxaheptadecyl azide
EINECS	Contact for details

Quality Control

Our Thiol-Dpeg5-Azido is manufactured under strict quality protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and maintain stability. Allow the product to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.