Description

T-Boc-n-Amido-Peg5-Acid is a heterobifunctional polyethylene glycol (PEG) derivative featuring a tert-butyloxycarbonyl (Boc)-protected amine at one terminus and a carboxylic acid at the other. This compound is a critical building block in bioconjugation and pharmaceutical development, enabling the controlled linkage of molecules with precise spacing and solubility. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceuticals, proteomics, and advanced material science for creating stable, water-soluble conjugates such as antibody-drug conjugates (ADCs) and peptide-PEG hybrids.

Application

• Bioconjugation Linker: Serves as a versatile spacer for coupling peptides, proteins, or antibodies to drugs, dyes, or solid surfaces.
• Antibody-Drug Conjugate (ADC) Development: Used to construct the PEG-based linker-payload systems that connect cytotoxic drugs to monoclonal antibodies.
• Peptide Modification: Enhances the solubility, stability, and pharmacokinetic properties of therapeutic peptides through site-specific PEGylation.
• Polymer Chemistry: Acts as a functional monomer or cross-linking agent for synthesizing specialized hydrogels and smart biomaterials.
• Diagnostic Reagents: Employed in the fabrication of biosensors and immunoassay components where controlled surface functionalization is required.
• Drug Delivery Systems: Incorporated into nanocarriers like liposomes and micelles to improve drug loading capacity and target specificity.

Basic Information

Product Name	T-Boc-n-Amido-Peg5-Acid
CAS No.	1347750-78-0
Molecular Formula	C24H45NO10
Molecular Weight	507.62 g/mol
Synonyms	1-Boc-amino-3,6,9,12,15-pentaoxa-18-azaoctadecan-18-oic acid; Boc-NH-PEG5-COOH; Boc-Amino-PEG5-Acid; tert-Butyl (17-carboxy-3,6,9,12,15-pentaoxa-17-azaheptadecyl)carbamate; 2-[2-[2-[2-[2-[(2-{[(tert-butoxy)carbonyl]amino}ethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid; Boc-N-amido-PEG5-acid; T-Boc-NH-PEG5-CH2CH2COOH
EINECS	Contact for details

Quality Control

Our T-Boc-n-Amido-Peg5-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) with detailed specifications are available upon request to support your research and cGMP-compliant production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.