Description

Cbz-n-Amido-Peg5-Acid CAS NO 1347750-74-6 is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a carboxybenzyl (Cbz) protecting group and a terminal carboxylic acid. This bifunctional linker is essential for constructing complex molecular architectures, offering controlled conjugation and enhanced solubility in aqueous and organic media. It is a critical building block for researchers and manufacturers in pharmaceutical development, bioconjugation, and advanced material science, enabling the creation of targeted drug delivery systems, peptide modifications, and functional hydrogels.

Application

• Bioconjugation and Linker Chemistry: Serves as a versatile heterobifunctional crosslinker for coupling amines to various functional groups (e.g., NHS esters, amines) in antibody-drug conjugates (ADCs) and protein-polymer hybrids.
• Peptide and Prodrug Synthesis: Used to introduce PEG spacers and Cbz-protected amines into peptide sequences or prodrug molecules to improve pharmacokinetic properties like solubility and circulation half-life.
• Polymer and Dendrimer Functionalization: Acts as a key monomer or chain extender for synthesizing functionalized PEG-based polymers, dendrimers, and smart materials with tailored surface chemistry.
• Drug Delivery System Development: Incorporated into the design of micelles, liposomes, and nanoparticles to provide a reactive handle for attaching targeting ligands or therapeutic payloads.
• Surface Modification and Biocompatible Coatings: Utilized to graft PEG chains onto surfaces (e.g., medical devices, biosensors) to create non-fouling, biocompatible interfaces with specific reactive sites for further coupling.
• Research and Diagnostic Reagents: Employed in the development of assay components, fluorescent probes, and diagnostic conjugates where a defined, hydrophilic spacer is required.

Basic Information

Product Name	Cbz-n-Amido-Peg5-Acid
CAS No.	1347750-74-6
Molecular Formula	C27H45NO11
Molecular Weight	559.65 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-3,6,9,12,15-pentaoxa-2-azaheptadecan-17-oic Acid; 17-[(Benzyloxy)carbonyl]amino-3,6,9,12,15-pentaoxaheptadecanoic Acid; Carbobenzoxy-PEG5-acid; Cbz-NH-PEG5-COOH; Fmoc-N-amido-PEG5-acid (related); Amino-PEG5-acid-Cbz; Z-NH-PEG5-COOH; N-Carbobenzyloxy-3,6,9,12,15-pentaoxa-2-azaheptadecan-17-oic Acid
EINECS	Contact for details

Quality Control

Our Cbz-n-Amido-Peg5-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification, to ensure it meets the high standards required for research and cGMP manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); desiccate for long-term storage. Keep container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by titration)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.