Description

Dehydro Warfarin-D5 is a high-purity, isotopically labeled internal standard critical for advanced analytical applications. This compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical research laboratories, contract research organizations (CROs), and regulatory testing facilities that require definitive analytical methods.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the precise quantification of warfarin and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic (PK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and preclinical research.
• Therapeutic Drug Monitoring (TDM): Supports the development and validation of robust assays for monitoring warfarin levels in patient samples to optimize dosage and ensure therapeutic efficacy.
• Metabolite Identification & Profiling: Aids in the identification and structural elucidation of warfarin metabolites using high-resolution mass spectrometry.
• Method Development & Validation: Serves as a critical reference material for developing, optimizing, and validating bioanalytical methods according to FDA, EMA, and ICH guidelines.
• Forensic & Anti-Doping Analysis: Employed in specialized testing laboratories for the definitive identification and quantification of warfarin in forensic and sports doping control samples.

Basic Information

Product Name	Dehydro Warfarin-D5
CAS No.	1346606-43-6
Molecular Formula	C19H11D5O4
Molecular Weight	313.36 g/mol
Synonyms	4-Hydroxy-3-(3-oxo-1-phenylpentyl)-2H-1-benzopyran-2-one-d5; (RS)-Warfarin-d5; 3-(α-Acetonylbenzyl)-4-hydroxycoumarin-d5; Warfarin-d5 (dehydro); Coumadin-d5 (dehydro); Marevan-d5; Isotopically Labeled Warfarin-d5; Deuterated Warfarin Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Dehydro Warfarin-D5 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including HPLC, NMR, and Mass Spectrometry to confirm identity, purity, and isotopic enrichment. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request to support your regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.