Description

4-Chloro Bupropion-D9 Fumarate is a high-purity, deuterated analog of the active pharmaceutical ingredient bupropion, specifically designed for advanced research and analytical applications. This stable isotope-labeled compound is essential for precise pharmacokinetic and metabolic studies, providing superior internal standards for mass spectrometry. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug development and bioanalytical method validation.

Application

• As a certified reference standard for the quantitative analysis of bupropion and its metabolites in biological matrices via LC-MS/MS.
• As an internal standard in pharmacokinetic (PK) and pharmacodynamic (PD) studies to ensure data accuracy and reproducibility.
• For use in drug metabolism and disposition (DMPK) research to trace metabolic pathways and identify metabolites.
• In the development and validation of bioanalytical methods according to FDA, EMA, and ICH guidelines.
• For quality control and impurity profiling in the manufacturing of active pharmaceutical ingredients (APIs).
• In forensic and clinical toxicology to accurately quantify bupropion levels.

Basic Information

Product Name	4-Chloro Bupropion-D9 Fumarate
CAS No.	1346606-37-8
Molecular Formula	C13H9D9ClNO • C4H4O4
Molecular Weight	Contact for details
Synonyms	Bupropion-d9 4-Chloro Fumarate; 4-Chloro-2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one-d9 Fumarate; (±)-2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-one-2,3,3,3-d4,1-d,1'-d4 4-Chloro Fumarate; Deuterated Bupropion Chloro Analog Fumarate Salt; Amfebutamone-d9 4-Chloro Fumarate; Zyban-d9 4-Chloro Fumarate (labeled); Wellbutrin-d9 4-Chloro Fumarate (labeled)
EINECS	Contact for details

Quality Control

Our 4-Chloro Bupropion-D9 Fumarate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and MS, to ensure high chemical and isotopic purity and compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical results is provided with every shipment to guarantee traceability and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.