Description

Desbutyl Lumefantrine-D9 is a high-purity, deuterium-labeled internal standard critical for accurate quantitative analysis in pharmaceutical research and development. This stable isotope-labeled compound is essential for ensuring the precision and reliability of mass spectrometry-based methods, particularly in pharmacokinetic and bioanalytical studies. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies focused on antimalarial drug development and quality control.

Application

• Internal Standard for LC-MS/MS: Serves as a crucial reference compound for the precise quantification of lumefantrine and its metabolites in complex biological matrices like plasma and serum.
• Pharmaceutical R&D: Enables accurate pharmacokinetic (PK) and pharmacodynamic (PD) studies during the development and clinical trials of antimalarial medications.
• Bioanalytical Method Development: Used to validate and optimize analytical methods, ensuring high specificity, accuracy, and reproducibility in drug metabolism studies.
• Doping Control & Forensic Analysis: Supports high-confidence detection and confirmation of lumefantrine in forensic and anti-doping applications.
• Metabolite Identification & Profiling: Aids in the structural elucidation and tracking of drug metabolite pathways.
• Quality Assurance/Quality Control (QA/QC): Employed in-house by manufacturers to maintain batch-to-batch consistency and verify the purity of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Desbutyl Lumefantrine-D9
CAS No.	1346606-35-6
Molecular Formula	C28H23Cl3D9NO3
Molecular Weight	~528.9 g/mol
Synonyms	Desbutyl Lumefantrine d9; 2,7-Dichloro-9-[(2-dichlorophenyl)methyl]-α-[(dibutyl-d9)amino]-4-fluorenemethanol; Lumefantrine Desbutyl-d9; N-Desbutyl Lumefantrine-D9; Lumefantrine Desbutyl Metabolite-d9; Benflumetol Desbutyl-d9; Internal Standard for Lumefantrine-d9; Coartem Metabolite Standard-d9
EINECS	Contact for details

Quality Control

Every batch of Desbutyl Lumefantrine-D9 is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) that detail purity, isotopic enrichment, and impurity profiles, ensuring compliance with the stringent requirements of analytical and pharmaceutical reference standards. Our quality commitment supports applications under GMP/GLP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (Enrichment)	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.