Description

5,6-Dihydro-3-(Methylamino)-2H-1,4-Thiazin-2-One Oxime-D3 Hydrochloride is a high-purity, deuterium-labeled chemical reference standard, distinguished by its isotopic purity and structural specificity. This compound is critical for ensuring analytical accuracy and method validation in advanced research and development. It is primarily utilized by pharmaceutical researchers and analytical laboratories engaged in pharmacokinetic studies, metabolic pathway tracing, and the development of deuterated active pharmaceutical ingredients (APIs).

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a stable, non-interfering reference for the precise quantification of its non-deuterated counterpart in complex biological matrices.
• Metabolic Pathway Tracing: Used in drug metabolism and pharmacokinetics (DMPK) studies to track and identify metabolites, leveraging the deuterium label for differentiation.
• Deuterated API Development: Acts as a key intermediate or reference material in the synthesis and quality control of deuterium-enriched pharmaceutical compounds.
• Biomedical Research: Employed in proteomics and biomarker discovery research where precise isotopic labeling is required for accurate mass spectrometry.
• Regulatory Compliance & Method Validation: Essential for developing and validating analytical methods to meet stringent regulatory requirements (e.g., FDA, EMA) for new drug applications.
• Stable Isotope Labeling Studies: Facilitates research in chemical reaction mechanisms and stability studies where isotopic effects are investigated.

Basic Information

Item	Detail
Product Name	5,6-Dihydro-3-(Methylamino)-2H-1,4-Thiazin-2-One Oxime-D3 Hydrochloride
CAS No.	1346606-31-2
Molecular Formula	C6H7D3ClN3OS
Molecular Weight	207.69 g/mol
Synonyms	3-(Methylamino)-5,6-dihydro-2H-1,4-thiazin-2-one oxime-d3 hydrochloride; Deuterated Thiazinone Oxime Hydrochloride; (Methyl-d3-amino)-5,6-dihydro-2H-1,4-thiazin-2-one oxime HCl; 1346606-31-2; 5,6-Dihydro-3-[(methyl-d3)amino]-2H-1,4-thiazin-2-one oxime hydrochloride; Oxime-D3 Hydrochloride derivative of 5,6-Dihydro-3-(methylamino)-2H-1,4-thiazin-2-one
EINECS	Contact for details

Quality Control

Every batch of 5,6-Dihydro-3-(Methylamino)-2H-1,4-Thiazin-2-One Oxime-D3 Hydrochloride is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with high-purity reference standard requirements, with a focus on isotopic purity, chemical purity, and structural identity. A detailed Certificate of Analysis (COA) providing batch-specific data from NMR, HPLC, and MS is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.