Description

All-Trans 4-Keto Retinoic Acid-(9-Methyl)-D3 is a high-purity, synthetic vitamin D3 derivative and retinoic acid analog designed for advanced research and development. This compound is valued for its specific molecular structure, which makes it a critical intermediate and reference standard in the study of cell differentiation and signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and manufacturers of high-end active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate in the synthesis of novel retinoid and vitamin D-based therapeutics targeting dermatological and oncological conditions.
• Biochemical Reference Standard: Used as a high-purity analytical standard for method development, validation, and quality control in HPLC and LC-MS assays.
• Cell Biology Studies: Employed in vitro to investigate mechanisms of cell proliferation, differentiation, and apoptosis mediated by nuclear receptor pathways.
• Cosmeceutical Ingredient Development: Explored for potential use in advanced anti-aging and skin-rejuvenation formulations due to its retinoic acid activity.
• Chemical Synthesis: Acts as a specialized building block for the preparation of other structurally complex vitamin D and retinoid analogs.

Basic Information

Product Name	All-Trans 4-Keto Retinoic Acid-(9-Methyl)-D3
CAS No.	1346606-26-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(9-Methyl)-4-Keto Retinoic Acid D3; 4-Oxo-9-methyl-retinoic acid D3 derivative; All-trans-4-Keto-9-methyl-retinoic acid vitamin D3 analog; 9-Methyl-4-ketoretinoic acid D3; Vitamin D3-retinoic acid hybrid compound; Retinoid-Vitamin D3 conjugate; 1346606-26-5; 4-Keto-9-methyl-retinoic acid-D3
EINECS	Contact for details

Quality Control

Our All-Trans 4-Keto Retinoic Acid-(9-Methyl)-D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.