Description

Propafenone-D5 Hydrochloride is a deuterated internal standard of the Class IC antiarrhythmic drug, propafenone, specifically labeled with five deuterium atoms. This high-purity reference material is essential for ensuring the accuracy and reliability of quantitative bioanalytical methods, such as LC-MS/MS, in pharmacokinetic and metabolism studies. It is a critical tool for pharmaceutical R&D laboratories, clinical research organizations, and regulatory bodies requiring precise and unambiguous analytical data.

Application

• Primary use as an Internal Standard for the quantification of propafenone in biological matrices (plasma, serum, urine) via mass spectrometry.
• Method development and validation in pharmacokinetic (PK) and bioequivalence studies for generic and innovator drug formulations.
• Metabolite profiling and drug metabolism studies to understand the biotransformation pathways of propafenone.
• Quality control and assurance in clinical trial sample analysis, ensuring data integrity for regulatory submissions.
• Use in forensic and toxicological analysis for the accurate determination of propafenone levels.
• Supporting research in cardiac electrophysiology where precise measurement of drug concentration is required.

Basic Information

Product Name	Propafenone-D5 Hydrochloride
CAS No.	1346605-05-7
Molecular Formula	C21H22D5ClNO2 • HCl
Molecular Weight	406.39 g/mol (approx.)
Synonyms	1-[2-Hydroxy-3-(propylamino)propoxy]-3-phenylpropiophenone-D5 Hydrochloride; 2'-[2-Hydroxy-3-(propylamino)propoxy]-3-phenylpropiophenone-D5 Hydrochloride; (±)-Propafenone-D5 Hydrochloride; Propafenone (phenyl-d5) Hydrochloride; Propafenone-d5 HCl; 3-Phenyl-1-{2-[(propyl-d7)amino]-1-(hydroxy-d)propoxy}propiophenone Hydrochloride (fully deuterated variant); Rytmonorm-D5 Hydrochloride (deuterated variant).
EINECS	Contact for details

Quality Control

Every batch of our Propafenone-D5 HCl is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and confirming the absence of interfering impurities. Our quality commitment ensures the material meets the exacting standards required for regulatory-grade analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (chemical purity)
Isotopic Purity (MS)	≥98.0 atom % D (D5 enrichment)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.