Description

Fty720-D4 Hydrochloride is a deuterated, high-purity chemical reference standard of significant importance in pharmaceutical research and development. This compound is critical for enabling precise analytical studies, particularly in the fields of drug metabolism and pharmacokinetics (DMPK). It is primarily needed by research institutions, pharmaceutical companies, and CROs (Contract Research Organizations) engaged in the development of sphingosine-1-phosphate (S1P) receptor modulators and related therapeutic agents.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a stable, isotopically labeled internal standard for the accurate quantification of Fingolimod (FTY720) and its metabolites in complex biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for conducting mass spectrometry-based assays to study absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Used as a critical reagent in developing and validating robust, GLP-compliant analytical methods for regulatory submissions.
• Stable Isotope Tracing Experiments: Enables researchers to trace metabolic pathways and understand the biotransformation of S1P receptor modulators within biological systems.
• Pharmaceutical Impurity Profiling: Aids in the identification and characterization of process-related impurities and degradants during drug substance and product development.
• Reference Material for Quality Control: Provides a certified reference material for in-house quality control laboratories to ensure the accuracy and precision of their analytical results.

Basic Information

Product Name	Fty720-D4 Hydrochloride
CAS No.	1346604-90-7
Molecular Formula	C19H29D4ClNO2•HCl
Molecular Weight	384.37 g/mol (approx.)
Synonyms	Fingolimod-D4 Hydrochloride; 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol-D4 Hydrochloride; FTY720-D4 HCl; FTY 720-d4 Hydrochloride; (2S)-2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol-1,1,3,3-d4 Dihydrochloride; 2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol-1,1,3,3-d4 Dihydrochloride; S1P Receptor Modulator-D4 HCl
EINECS	Contact for details

Quality Control

Our Fty720-D4 Hydrochloride is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chemical purity, isotopic purity (D-enrichment), and chromatographic profile. We adhere to relevant industry standards for reference materials, and our quality commitment ensures reliable and reproducible performance in your critical research workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms to structure
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.