Description

N,n-Dimethyl-3-Butyl-1H-Indene-2-Ethanamine-D9 Hydrobromide is a deuterated, isotopically labeled small-molecule amine derivative designed for high-precision applications in pharmaceutical research and analytical chemistry. Its stable deuterium labeling (D9) enables reliable quantitation and metabolic pathway tracing in mass spectrometry–based studies, offering superior signal-to-noise resolution over non-labeled analogs. This compound is essential for contract research organizations (CROs), API developers, and regulatory bioanalytical laboratories requiring reference standards with certified isotopic integrity and batch-to-batch reproducibility.

Application

• Internal standard in LC-MS/MS bioanalysis of indene-based drug candidates and metabolites
• Reference material for method validation and calibration curve generation in pharmacokinetic (PK) and toxicokinetic (TK) studies
• Tracer compound in mechanistic metabolism studies to distinguish endogenous vs. exogenous compound contributions
• Stable isotope-labeled control for quantitative structure–activity relationship (QSAR) modeling in CNS-active indene derivatives
• Tool compound in radioligand binding assay development where deuterium substitution minimizes kinetic isotope effects
• Quality control standard for GMP-compliant manufacturing of deuterated active pharmaceutical ingredients (APIs)

Basic Information

Product Name	N,n-Dimethyl-3-Butyl-1H-Indene-2-Ethanamine-D9 Hydrobromide
CAS No.	1346604-86-1
Molecular Formula	C17D9BrN2
Molecular Weight	351.27 g/mol
Synonyms	NDM-3BIEA-D9 HBr; N,N-Dimethyl-3-butyl-1H-indene-2-ethanamine-d9 hydrobromide; 2-(Dimethylamino)ethyl-3-butylindene-d9 hydrobromide; 1H-Indene-2-ethanamine, N,N-dimethyl-3-butyl-, d9, hydrobromide; Indene-2-ethanamine-d9, N,N-dimethyl-3-butyl-, monohydrobromide; CAS 1346604-86-1; D9-labeled 3-butylindene ethylamine HBr salt
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is verified for isotopic enrichment (≥98% D-incorporation at designated positions), chemical purity (≥99.0% by HPLC), and structural identity (NMR, IR, MS). Certificates of Analysis (COA) are available upon request and include full spectral data, residual solvent analysis, and heavy metal screening per ICH Q3D guidelines. Manufactured under ISO 9001-certified quality management systems with traceability to primary reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C under dry, inert conditions due to hygroscopic nature. Minimize exposure to ambient humidity and handle only in a controlled environment with desiccated glove box or nitrogen-purged vial transfer.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to reference 1H- and 2H-NMR spectra
Assay (HPLC)	≥99.0%
Isotopic Purity (MS)	≥98% D9 incorporation
Residual Solvents (GC)	Meets ICH Q3C limits
Water Content (KF)	≤0.5%
Heavy Metals (ICH Q3D)	Complies with Class 3 limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.