Description

Cis (2,3)-Dihydro Tetrabenazine-D6 is a deuterated isotopologue of a key pharmaceutical intermediate, specifically designed for advanced research and development. This high-purity labeled compound is essential for creating internal standards in quantitative mass spectrometry, ensuring unparalleled accuracy in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on neurology and CNS drug development.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference standard for the precise quantification of Tetrabenazine and its metabolites in complex biological matrices like plasma and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracing of drug absorption, distribution, metabolism, and excretion (ADME) pathways in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Used to establish robust, sensitive, and specific analytical methods compliant with FDA and ICH guidelines.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-accuracy assays to minimize matrix effects and improve data reliability for regulatory submissions.
• Neurological Research: Supports investigative studies on vesicular monoamine transporter 2 (VMAT2) inhibitors and related therapeutic mechanisms.
• Quality Control in Pharmaceutical Manufacturing: Acts as a reference material for in-process testing and final product release of related active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Cis (2,3)-Dihydro Tetrabenazine-D6
CAS No.	1346604-77-0
Molecular Formula	C19H21D6NO3
Molecular Weight	323.45 g/mol (approx.)
Synonyms	(+)-α-Dihydrotetrabenazine-d6; (3R,11bR)-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one-d6; Deutetrabenazine-d6 (cis isomer); Tetrabenazine D6 metabolite; VMAT2 Inhibitor-d6; TBZ-D6; Nitoman-d6 (labeled); Xenazine-d6 (labeled)
EINECS	Contact for details

Quality Control

Every batch of Cis (2,3)-Dihydro Tetrabenazine-D6 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity (by HPLC), isotopic enrichment, and related substance profiles to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.