Description

Didesmethyl Almotriptan-D4 CAS NO 1346604-75-8 is a high-purity, deuterium-labeled internal standard critical for advanced analytical applications. This stable isotope-labeled compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses, particularly in pharmacokinetic and metabolism studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in method development and validation for drug substance and metabolite analysis.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in Liquid Chromatography-Tandem Mass Spectrometry for the precise measurement of almotriptan and its metabolites in biological matrices.
• Pharmacokinetic (PK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Bioanalytical Method Development: Serves as a critical component in developing and validating robust, sensitive, and specific analytical methods for drug quantification.
• Drug Metabolism Studies: Facilitates the identification and quantification of drug metabolites, aiding in understanding metabolic pathways.
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and assay validation of active pharmaceutical ingredients (APIs) to ensure batch-to-batch consistency.
• Regulatory Submissions: Provides essential data traceability and method validation support for filings with agencies like the FDA and EMA.

Basic Information

Item	Details
Product Name	Didesmethyl Almotriptan-D4
CAS No.	1346604-75-8
Molecular Formula	C₁₇H₂₁D₄N₃O₂S
Molecular Weight	Contact for details
Synonyms	1-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-N-methylmethanesulfonamide-d4; Almotriptan Didesmethyl Metabolite-d4; Almotriptan Impurity-d4; Deuterated Didesmethyl Almotriptan; [²H₄]-Didesmethyl Almotriptan; STI Didesmethyl Almotriptan-d4; Internal Standard for Almotriptan-d4
EINECS	Contact for details

Quality Control

Every batch of Didesmethyl Almotriptan-D4 is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity, verified by advanced techniques including NMR, HPLC, and Mass Spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, assay, and deuterium enrichment. Our quality commitment ensures the material meets the stringent requirements for use as a certified reference standard in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated place. For long-term storage, consider storing desiccated under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.