Description

n-Desmethyl Almotriptan-D3 is a high-purity, deuterium-labeled internal standard critical for accurate quantitative analysis in bioanalytical research. This compound is essential for ensuring precision and reliability in mass spectrometry-based assays, particularly for pharmacokinetic and metabolism studies. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical chemists specializing in method development and validation for drug substance analysis.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound for the precise quantification of Almotriptan and its metabolites in biological matrices such as plasma, serum, and urine.
• Pharmacokinetic (PK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Bioanalytical Method Development: Used as a key component in developing and validating robust, sensitive, and specific analytical methods compliant with FDA and EMA guidelines.
• Metabolite Identification & Profiling: Aids in the structural elucidation and quantification of drug metabolites to understand biotransformation pathways.
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and assay validation of the active pharmaceutical ingredient (API) to ensure batch-to-batch consistency.
• Forensic & Doping Analysis: Applicable in specialized testing where precise measurement of triptan-class compounds is required.

Basic Information

Product Name	n-Desmethyl Almotriptan-D3
CAS No.	1346604-71-4
Molecular Formula	C₁₆H₁₈D₃N₃O₂S
Molecular Weight	~ 316.42 g/mol
Synonyms	Almotriptan N-Desmethyl-D3; Almotriptan-d3 Desmethyl Metabolite; 3-[2-(Dimethylamino)ethyl]-5-(pyrrolidin-1-ylsulfonyl)-1H-indole-d3; 1-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]sulfonyl]pyrrolidine-d3; Deuterated n-Desmethyl Almotriptan; Almotriptan Metabolite Standard-d3; ALS-D3; Contact for additional synonyms.
EINECS	Contact for details.

Quality Control

Every batch of n-Desmethyl Almotriptan-D3 is manufactured and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles, ensuring compliance with research and development standards. Our quality commitment supports applications requiring data integrity for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated place. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 99.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.