Description

Candesartan-D4 CAS NO 1346604-70-3 is a high-purity, stable isotope-labeled analog of the angiotensin II receptor antagonist Candesartan. This deuterated compound is an essential internal standard for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly Liquid Chromatography-Mass Spectrometry (LC-MS/MS). It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug metabolism, pharmacokinetic (DMPK) studies, and clinical trial sample analysis.

Application

• Primary use as an internal standard for the precise quantification of Candesartan in biological matrices (plasma, serum, urine) via LC-MS/MS.
• Critical component in pharmacokinetic (PK) and bioequivalence studies to monitor drug concentration over time.
• Supporting drug metabolism and disposition (DMPK) research in preclinical and clinical development phases.
• Enhancing data integrity in regulatory submissions to agencies like the FDA and EMA by providing validated analytical methods.
• Used in forensic and anti-doping analysis for the accurate detection of the parent compound.
• Application in stable isotope dilution analysis to correct for analyte loss during sample preparation.

Basic Information

Product Name	Candesartan-D4
CAS No.	1346604-70-3
Molecular Formula	C24H16D4N6O3
Molecular Weight	428.46 g/mol
Synonyms	2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic Acid-d4; (±)-1-Hydroxyethyl 1-(Candesartan-d4); TCV-116-d4; CV-11974-d4; (Biphenyl-2-yl)tetrazole-d4 Candesartan; Deuterated Candesartan; Candesartan (tetrazole-d4)
EINECS	Contact for details

Quality Control

Our Candesartan-D4 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity, critical for its role as an analytical standard. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment (typically ≥98% D), chemical purity (by HPLC), and identity confirmation (by NMR and MS). We adhere to relevant GMP principles for laboratory chemicals to guarantee batch-to-batch consistency and traceability for your regulated studies.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Isotopic Purity (D-enrichment)	≥ 98% (by MS)
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.