Description

n-tert-Butoxycarbonyl-4-(Acrylanilido)Piperidine is a high-purity, advanced pharmaceutical intermediate featuring a piperidine scaffold protected by a Boc (tert-butoxycarbonyl) group and functionalized with an acrylanilido moiety. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates. Its unique structure makes it particularly valuable for targeting central nervous system (CNS) disorders, pain management, and other therapeutic areas requiring complex heterocyclic architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) for neurological and psychiatric disorders.
• Medicinal Chemistry R&D: Used in structure-activity relationship (SAR) studies and lead optimization for novel drug discovery programs.
• Protease Inhibitor Synthesis: Serves as a precursor in the development of protease inhibitors and other enzyme-targeted therapies.
• Kinase Inhibitor Development: Employed in the construction of complex molecules targeting various kinase pathways in oncology.
• Peptidomimetic Chemistry: Integral for creating peptidomimetics and conformationally constrained peptide analogs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	n-tert-Butoxycarbonyl-4-(Acrylanilido)Piperidine
CAS No.	1346604-69-0
Molecular Formula	C19H26N2O3
Molecular Weight	330.43 g/mol
Synonyms	4-(Acrylanilido)-1-Boc-piperidine; 1-Boc-4-(acryloylamino)piperidine; 1-(tert-Butoxycarbonyl)-4-[(1-oxo-2-propen-1-yl)amino]piperidine; tert-Butyl 4-(acryloylamino)piperidine-1-carboxylate; 4-Acrylamido-1-Boc-piperidine; N-Boc-4-acrylamidopiperidine; 4-(Acryloylamino)-1-N-Boc-piperidine; 1-N-Boc-4-acrylamidopiperidine
EINECS	Contact for details

Quality Control

Our n-tert-Butoxycarbonyl-4-(Acrylanilido)Piperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.