Description

3-Deschloro-2-Chloro Bupropion-D9 Hydrochloride is a high-purity, deuterium-labeled analog of a key pharmaceutical intermediate. This compound is specifically designed for use as an internal standard in quantitative analytical methods, providing superior accuracy and reliability in mass spectrometry. It is essential for researchers and quality control laboratories in the pharmaceutical and contract research organization (CRO) sectors who require precise metabolite tracking, pharmacokinetic studies, and method validation. The product is supplied with a guaranteed certificate of analysis to ensure traceability and data integrity.

Application

• Primary use as an internal standard for LC-MS/MS and GC-MS analysis in bioanalytical studies.
• Critical component in pharmacokinetic (PK) and pharmacodynamic (PD) research for accurate quantification of metabolites.
• Method development and validation in pharmaceutical quality control (QC) and stability testing.
• Supporting drug metabolism and disposition (DMPK) studies in preclinical and clinical research.
• Use in forensic and anti-doping analysis for definitive substance identification and quantification.
• Reference material for academic research in medicinal chemistry and analytical method development.

Basic Information

Product Name	3-Deschloro-2-Chloro Bupropion-D9 Hydrochloride
CAS No.	1346604-03-2
Molecular Formula	C13H9D9Cl2NO • HCl
Molecular Weight	Contact for details
Synonyms	Bupropion-d9 Metabolite Hydrochloride; 2-Chloro-3'-deschloro Bupropion-d9 HCl; (±)-2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-one-d9 Hydrochloride; 3-Deschloro-2-Chloro Bupropion Deuterated Hydrochloride; Bupropion D9 Derivative; 3-Chloro-α-(tert-butylamino)propiophenone-d9 Hydrochloride; BUP-d9 Metabolite Standard; 1346604-03-2
EINECS	Contact for details

Quality Control

Every batch of 3-Deschloro-2-Chloro Bupropion-D9 Hydrochloride is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure the highest standards of chemical purity and isotopic enrichment. Our quality assurance protocol includes identity confirmation, purity assay, and verification of deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing batch-specific results from HPLC, NMR, and MS is provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry place. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D9)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.