Description

n-Denitroso-Na€-Nitroso Lomustine-D4 is a deuterated isotopologue of a nitrosourea derivative, specifically designed for use as a high-purity analytical standard. This compound is critical for ensuring accuracy and reliability in quantitative mass spectrometry and pharmacokinetic studies. It is primarily utilized by pharmaceutical research laboratories, contract research organizations (CROs), and academic institutions engaged in advanced analytical chemistry and drug metabolism research.

Application

• Internal Standard for LC-MS/MS: Serves as a stable, isotopically labeled internal standard for the precise quantification of lomustine and its metabolites in complex biological matrices.
• Pharmacokinetic and Bioanalytical Research: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) studies in preclinical and clinical research.
• Method Development and Validation: Used as a reference material to develop, optimize, and validate sensitive and specific analytical methods in regulatory environments.
• Metabolite Identification: Aids in the structural elucidation and confirmation of drug metabolites using mass spectrometry.
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and assay verification for active pharmaceutical ingredients (APIs) and finished drug products.
• Toxicology Studies: Facilitates the investigation of drug toxicity and safety profiles by providing a reliable benchmark for concentration measurements.

Basic Information

Item	Detail
Product Name	n-Denitroso-Na€-Nitroso Lomustine-D4
CAS No.	1346603-97-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Lomustine-d4; 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea-d4; CCNU-d4; NSC-79037-d4; Ceenu-d4; 1-Nitroso-1-(2-chloroethyl)-3-(cyclohexyl)urea-d4; Isotopically Labeled Lomustine
EINECS	Contact for details

Quality Control

Every batch of n-Denitroso-Na€-Nitroso Lomustine-D4 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity suitable for demanding analytical applications. Comprehensive testing includes assay by HPLC, determination of isotopic enrichment by mass spectrometry, and identification by spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.