Description

n-Demethyl Vandetanib-D4 CAS NO 1346603-93-7 is a deuterated isotopologue of a key pharmaceutical intermediate, specifically designed for advanced research and development. This compound is essential for use as an internal standard in quantitative bioanalytical methods, such as LC-MS/MS, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers engaged in the development and quality control of targeted cancer therapies.

Application

• Primary use as a stable isotope-labeled internal standard for the precise quantification of Vandetanib and its metabolites in biological matrices.
• Critical component in bioanalytical method development and validation for clinical and pre-clinical studies.
• Enables accurate pharmacokinetic (PK) and pharmacodynamic (PD) profiling in drug development pipelines.
• Supports drug metabolism and excretion (DMPK) studies to understand the metabolic pathways of tyrosine kinase inhibitors.
• Used in quality control laboratories for ensuring the accuracy of analytical results in pharmaceutical manufacturing.
• Facilitates research into the mechanisms of action and resistance associated with RET and EGFR kinase inhibitors.

Basic Information

Product Name	n-Demethyl Vandetanib-D4
CAS No.	1346603-93-7
Molecular Formula	C22H20D4ClN4O2
Molecular Weight	408.93 g/mol (deuterated form)
Synonyms	N-Desmethyl Vandetanib-d4; Vandetanib N-Desmethyl-d4; 4-[(4-Bromo-2-fluorophenyl)amino]-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline-d4; ZD6474 N-Desmethyl-d4; Caprelsa Impurity D4; Vandetanib Metabolite D4; Vandetanib-d4 Desmethyl Analog; RET Kinase Inhibitor Metabolite Standard-d4
EINECS	Contact for details

Quality Control

Our n-Demethyl Vandetanib-D4 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay by HPLC, isotopic purity (D-enrichment), and identification by spectroscopic methods. We adhere to cGMP principles for pharmaceutical reference standards, ensuring traceability, consistency, and reliability for critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.