Description

2,5-Dimethyl Celecoxib-D4 is a deuterated analog of the selective COX-2 inhibitor Celecoxib, specifically labeled at four positions. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug development and regulatory compliance testing for anti-inflammatory agents.

Application

• Internal Standard for LC-MS/MS: Primary use as a quantitative reference standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the precise measurement of Celecoxib and its metabolites in biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Facilitates accurate studies on the absorption, distribution, metabolism, and excretion (ADME) profile of Celecoxib in preclinical and clinical research.
• Bioanalytical Method Development & Validation: Serves as a critical component in developing, validating, and transferring robust analytical methods according to FDA, EMA, and ICH guidelines.
• Clinical Trial Support: Enables reliable therapeutic drug monitoring and pharmacokinetic analysis during clinical trials of Celecoxib-based formulations.
• Forensic and Anti-Doping Analysis: Used in specialized testing laboratories for the accurate identification and quantification of Celecoxib.
• Stable Isotope Labeling Studies: Employed in mechanistic studies to trace metabolic pathways and investigate drug-drug interactions.

Basic Information

Product Name	2,5-Dimethyl Celecoxib-D4
CAS No.	1346603-87-9
Molecular Formula	C17H10D4F3N3O2S
Molecular Weight	385.40 g/mol
Synonyms	Celecoxib-d4 (2,5-dimethyl); 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide-2,3,5,6-d4; Deuterated Celecoxib; Celecoxib Internal Standard; 2,3,5,6-tetradeutero-4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
EINECS	Contact for details

Quality Control

Every batch of 2,5-Dimethyl Celecoxib-D4 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and confirming the absence of significant unlabeled impurities. Our quality commitment ensures compliance with the stringent requirements of pharmaceutical R&D and bioanalytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.