Description

Butibufen-D5 is a deuterated analog of the non-steroidal anti-inflammatory drug (NSAID) Butibufen, specifically labeled with five deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical results. It is a critical tool for researchers and quality control laboratories in the pharmaceutical and contract research organization (CRO) sectors who require precise bioanalytical method development and drug metabolism studies.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the analysis of Butibufen.
• Pharmacokinetic and Metabolism Studies: Enables accurate tracking and quantification of Butibufen and its metabolites in biological matrices (e.g., plasma, urine) during ADME studies.
• Bioanalytical Method Development and Validation: Serves as a critical component in developing and validating robust, GLP-compliant analytical methods.
• Pharmaceutical Quality Control: Used in impurity profiling and assay determination of Butibufen in active pharmaceutical ingredient (API) and finished dosage forms.
• Forensic and Clinical Toxicology: Supports accurate quantification in forensic analysis and therapeutic drug monitoring.
• Stable Isotope Labeling Research: Used in mechanistic studies to investigate metabolic pathways and degradation products.

Basic Information

Product Name	Butibufen-D5
CAS No.	1346603-83-5
Molecular Formula	C15H17D5O2
Molecular Weight	~243.38 g/mol
Synonyms	2-(4-Isobutylphenyl)propionic-3,3,4,4,4-d5 acid; Deuterated Butibufen; Butibufen (phenyl-d5); 4-Isobutyl-α-methylbenzeneacetic-d5 Acid; (±)-2-(4-Isobutylphenyl)propionic-d5 Acid; Butibufen-d5 Internal Standard; Bufexamac-d5 (common error, correct is Butibufen-d5); 2-(4-(2-Methylpropyl)phenyl)propanoic-3,3,4,4,4-d5 acid
EINECS	Contact for details

Quality Control

Our Butibufen-D5 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is fully characterized and supplied with a comprehensive Certificate of Analysis (COA) detailing parameters such as assay (by HPLC), isotopic enrichment, and purity. We support compliance with GMP/GLP guidelines for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (chemical purity)
Isotopic Enrichment	≥98.0 atom % D
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.