Description

Adefovir-D4 Phosphate Triethylamine Salt is a high-purity, isotopically labeled derivative of the antiviral drug adefovir, specifically designed for use as an internal standard in quantitative bioanalytical methods. This compound is critical for ensuring the accuracy and reliability of pharmacokinetic and metabolism studies, providing a stable reference point with minimal interference from the analyte. It is an essential material for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on antiviral drug development and therapeutic drug monitoring.

Application

• Internal Standard for LC-MS/MS Analysis: Primary use as a stable, isotopically labeled internal standard for the precise quantification of adefovir and its metabolites in biological matrices (plasma, serum, urine).
• Pharmacokinetic and Bioavailability Studies: Enables accurate measurement of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Drug Metabolism Research: Used in metabolite identification and profiling studies to understand the biotransformation pathways of adefovir.
• Quality Control in Pharmaceutical Manufacturing: Supports analytical method development and validation for in-process testing and final product release of antiviral formulations.
• Forensic and Doping Control Analysis: Applied in specialized testing laboratories for the detection and confirmation of antiviral agents.

Basic Information

Product Name	Adefovir-D4 Phosphate Triethylamine Salt
CAS No.	1346603-65-3
Molecular Formula	C12H20D4N6O5P • C6H15N
Molecular Weight	Contact for details
Synonyms	9-[2-(Bis((2,2,2-trifluoroethoxy)phosphinyl)methoxy)ethyl]adenine-d4 Triethylamine Salt; PMEA-d4 Phosphate Triethylamine Salt; GS-0393-d4; Adefovir Dipivoxil Impurity-d4 (phosphate salt); Deuterated Adefovir Phosphate TEA Salt; [[2-(6-Amino-9H-purin-9-yl)ethoxy-d4]methyl]phosphonic Acid Triethylamine Salt
EINECS	Contact for details

Quality Control

Our Adefovir-D4 Phosphate Triethylamine Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, chemical purity, isotopic enrichment, and residual solvents. We support compliance with ICH Q2(R1) guidelines for analytical method validation, making this material suitable for GLP and GMP-regulated studies.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, keep under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥98.0 atom % D
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.