Description

Thiomuscimol-15N,D2 Hydrochloride is a high-purity, isotopically labeled derivative of the potent GABAA receptor agonist, thiomuscimol. This compound is specifically designed for advanced research applications where precise molecular tracking and metabolic studies are critical. It is an essential tool for neuroscientists, pharmacologists, and analytical chemists working in drug discovery, neuropharmacology, and mass spectrometry-based proteomics. The product is supplied as the hydrochloride salt to ensure stability and solubility for experimental use.

Application

• Biochemical Research & Neuropharmacology: Used as a labeled ligand in receptor binding assays and autoradiography studies to investigate GABAA receptor subtypes and function.
• Drug Discovery & Development: Serves as a critical internal standard in quantitative LC-MS/MS and GC-MS methods for the analysis of thiomuscimol and related compounds in pharmacokinetic and metabolic stability studies.
• Metabolic Pathway Tracing: The 15N and D2 labels enable precise tracking of the compound's fate in in vitro and in vivo metabolic studies.
• Proteomics & Biomarker Research: Facilitates the development of targeted mass spectrometry assays for the identification and quantification of proteins or biomarkers interacting with GABAergic systems.
• Chemical Reference Standard: Provides a certified, high-purity reference material for quality control and method validation in analytical laboratories.

Basic Information

Item	Detail
Product Name	Thiomuscimol-15N,D2 Hydrochloride
CAS No.	1346603-53-9
Molecular Formula	C4H5D215N2O2S • HCl
Molecular Weight	Contact for details
Synonyms	5-Aminomethyl-3-hydroxy-1,2-thiazole-15N,D2 Hydrochloride; (3-Hydroxy-5-(aminomethyl)isoxazol-4-yl)methanol-15N,D2 Hydrochloride; Labeled Thiomuscimol HCl; Isotopically Labeled GABA Agonist; [15N,D2]-Thiomuscimol Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Thiomuscimol-15N,D2 Hydrochloride is manufactured under strict quality management protocols. We guarantee high chemical and isotopic purity, verified by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, isotopic enrichment, and all relevant spectroscopic data to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (15N)	≥ 98 atom %
Isotopic Enrichment (D)	≥ 98 atom %
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.