Description

Secnidazole-D6 is a deuterium-labeled analog of the nitroimidazole antibiotic Secnidazole, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, such as LC-MS/MS, by correcting for variations in sample preparation and instrument performance. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS Analysis: Critical for the precise quantification of Secnidazole and its metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used in tracing and quantifying the parent drug during ADME (Absorption, Distribution, Metabolism, and Excretion) studies to understand drug behavior.
• Bioanalytical Method Development and Validation: Serves as a key component in establishing robust, sensitive, and regulatory-compliant analytical methods for clinical and non-clinical trials.
• Pharmaceutical Quality Control: Employed in impurity profiling and stability-indicating assays to monitor drug substance and product quality.
• Clinical Research: Facilitates accurate therapeutic drug monitoring and bioavailability/bioequivalence studies for generic drug development.

Basic Information

Product Name	Secnidazole-D6
CAS No.	1346603-27-7
Molecular Formula	C7H5D6N3O3
Molecular Weight	188.21 g/mol
Synonyms	1-(2-Methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol-1,1,2,3,3,3-d6; Secnidazole (hexadeuterated); Secnidazole-d6; [2H6]-Secnidazole; α,α,β,β,β,β-Hexadeutero-1-(2-methyl-5-nitroimidazol-1-yl)propan-2-ol; Deuterated Secnidazole; Stable Isotope Labeled Secnidazole
EINECS	Contact for details

Quality Control

Our Secnidazole-D6 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment, chemical purity (by HPLC), and residual solvent content. We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee reliable performance and traceability in your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 98.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.