Description

Reticuline-D3 is a deuterium-labeled isotopic analog of the natural benzylisoquinoline alkaloid reticuline, widely used as an internal standard in quantitative mass spectrometry-based metabolomics and pharmacokinetic studies. Its high isotopic purity and structural fidelity ensure precise analytical calibration and accurate quantification of endogenous reticuline and related alkaloids in complex biological matrices. This compound is essential for pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions conducting stable isotope dilution assays (SIDA). Reticuline-D3 CAS NO 1346603-23-3 supports reproducible, regulatory-compliant bioanalysis across global GLP and GCP environments.

Application

• Internal standard for LC-MS/MS quantification of reticuline in plasma, urine, and tissue homogenates
• Metabolic pathway tracing in plant alkaloid biosynthesis studies (e.g., morphine, codeine, berberine pathways)
• Pharmacokinetic and ADME (Absorption, Distribution, Metabolism, Excretion) studies of benzylisoquinoline alkaloids
• Reference material for method validation per ICH M10 and FDA Bioanalytical Method Validation Guidance
• Calibration standard in forensic toxicology for detection of opiate-related alkaloids
• Stable isotope dilution assay (SIDA) development for clinical biomarker discovery
• Quality control reference in herbal medicine standardization (e.g., poppy, barberry, goldenseal extracts)
• Isotopic tracer in enzymatic studies involving cytochrome P450 isoforms (CYP2D6, CYP3A4) and N-methyltransferases

Basic Information

Product Name	Reticuline-D3
CAS No.	1346603-23-3
Molecular Formula	C20H21D3NO4
Molecular Weight	342.41 g/mol
Synonyms	(S)-Reticuline-d3; (S)-1-(3',4'-Dihydroxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-d3; (S)-N-Methyl-3'-hydroxy-4'-methoxy-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-d3; (S)-Tetrahydroreticuline-d3; (S)-1-(3-Hydroxy-4-methoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-d3; (S)-Reticuline-2,2,2-d3; (S)-Reticuline-α,α,α-d3; (S)-N-Methyl-3-hydroxy-4-methoxy-6,7-dimethoxytetrahydroisoquinoline-d3
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch is verified for isotopic enrichment (>98% D incorporation at designated positions), chemical purity (≥99.0% by HPLC), identity (confirmed by MS and 1H-NMR), and absence of critical impurities (residual solvents ≤ ICH Q3C limits). Testing follows USP & EP general chapters for reference standards and adheres to ISO 17025-accredited laboratory practices.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (argon or nitrogen) to prevent degradation. Due to its hygroscopic nature, minimize exposure to ambient humidity and avoid repeated opening of the container. Allow to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (MS)	Conforms to reference spectrum
Identification (1H-NMR)	Conforms to reference spectrum
Assay (HPLC)	≥99.0%
Isotopic Enrichment (MS)	≥98% D at C-2, C-2′, C-2″ positions
Residual Solvents (GC)	Meets ICH Q3C Class 3 limits
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.