Description

Revaprazan-D3 Hydrochloride is a deuterated isotopologue of the proton pump inhibitor Revaprazan, specifically labeled with three deuterium atoms. This compound is of significant value as a stable isotope-labeled internal standard for the precise bioanalytical quantification of Revaprazan in complex matrices such as plasma and tissue samples during pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on advancing gastrointestinal therapeutics and ensuring accurate drug metabolism and pharmacokinetics (DMPK) data.

Application

• Primary use as a stable isotope-labeled internal standard for Liquid Chromatography-Mass Spectrometry (LC-MS/MS) bioanalysis.
• Quantification of Revaprazan in pharmacokinetic (PK) and toxicokinetic (TK) studies to determine absorption, distribution, metabolism, and excretion (ADME) profiles.
• Method development and validation in clinical and pre-clinical research for gastrointestinal acid-related disorders.
• Ensuring data accuracy and compliance in Good Laboratory Practice (GLP) and Good Clinical Practice (GCP) regulated environments.
• Metabolite identification and profiling studies to understand drug biotransformation pathways.
• Supporting generic drug development and bioequivalence testing for Revaprazan-based formulations.

Basic Information

Product Name	Revaprazan-D3 Hydrochloride
CAS No.	1346602-51-4
Molecular Formula	C24H26D3N4O2•HCl
Molecular Weight	Contact for details
Synonyms	5,6,7,8-Tetrahydro-3-[(1H-imidazol-1-yl)methyl]-2-[(2,2,2-trifluoroethoxy)methyl]pyrido[1,2-a]pyrimidin-4(3H)-one-d3 Hydrochloride; Revaprazan-d3 HCl; 1-[[2-[(2,2,2-Trifluoroethoxy)methyl]-4-oxo-5,6,7,8-tetrahydro-3H-pyrido[1,2-a]pyrimidin-3-yl]methyl]-1H-imidazole-d3 Hydrochloride; YH1885-d3 Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Revaprazan-D3 Hydrochloride is manufactured and analyzed under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request and provide detailed data on purity (HPLC), isotopic purity (MS), and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥98.0%
Isotopic Purity (MS)	≥99.0% D3
Chemical Purity (HPLC)	≥95.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.