Description

n-Desethyl Etifoxine-D5 is a deuterated isotopologue of the n-Desethyl metabolite of Etifoxine, a non-benzodiazepine anxiolytic agent. This stable-labeled compound is specifically designed for use as a high-purity internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in mass spectrometry-based assays. It is an essential tool for pharmaceutical researchers, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism and pharmacokinetics (DMPK) studies, therapeutic drug monitoring, and forensic toxicology.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the precise measurement of n-Desethyl Etifoxine and related metabolites in biological matrices.
• Pharmacokinetic & DMPK Studies: Critical for accurate determination of drug concentration-time profiles, bioavailability, and metabolic clearance rates during preclinical and clinical development.
• Forensic & Clinical Toxicology: Enables reliable identification and quantification of Etifoxine and its metabolites in human plasma, serum, or urine for diagnostic or legal purposes.
• Method Development & Validation: Serves as a key reference material for developing, optimizing, and validating robust bioanalytical assays in compliance with regulatory guidelines (e.g., FDA, EMA).
• Metabolite Profiling & Identification: Aids in the structural elucidation and tracking of metabolic pathways of Etifoxine in in vitro and in vivo studies.
• Quality Control in Reference Material Production: Used in the calibration and quality control of certified reference materials (CRMs) for clinical diagnostics.

Basic Information

Product Name	n-Desethyl Etifoxine-D5
CAS No.	1346602-46-7
Molecular Formula	C15H14D5ClN2O
Molecular Weight	279.81 g/mol
Synonyms	6-Chloro-2-ethylamino-4-methyl-4-phenyl-4H-3,1-benzoxazine-D5; 2-[(Ethyl-d5)amino]-6-chloro-4-methyl-4-phenyl-4H-3,1-benzoxazine; n-Desethyl Etifoxine d5; Etifoxine N-Desethyl Metabolite-D5; Etifoxine-d5 Desethyl Metabolite; Deuterated n-Desethyl Etifoxine; n-Desethyl Etifoxine (ethyl-d5)
EINECS	Contact for details

Quality Control

Our n-Desethyl Etifoxine-D5 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch undergoes rigorous testing, including analysis by NMR, HPLC, and mass spectrometry, to confirm identity, chemical purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storage under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Chemical Purity (by NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.