Description

Pleconaril-D8 is a deuterated isotopologue of the antiviral compound Pleconaril, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity reference material is essential for ensuring accuracy and reliability in pharmacokinetic, metabolic, and bioanalytical studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers working on antiviral drug development and quality control.

Application

• Internal Standard for LC-MS/MS and GC-MS analysis in bioanalytical studies.
• Quantitative reference material for pharmacokinetic (PK) and pharmacodynamic (PD) research.
• Metabolite identification and drug metabolism studies in preclinical and clinical research.
• Quality control and method validation in pharmaceutical manufacturing.
• Stable isotope-labeled tracer for mechanistic metabolic pathway investigations.
• Calibration standard for ensuring regulatory compliance in analytical testing (e.g., FDA, EMA submissions).

Basic Information

Product Name	Pleconaril-D8
CAS No.	1346602-36-5
Molecular Formula	C₂₇H₂₇D₈F₃N₂O₅
Molecular Weight	~532.6 g/mol
Synonyms	3-[3,5-Dimethyl-4-[[3-(3-methyl-5-isoxazolyl)propyl]oxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole-d8; Deuterated Pleconaril; Pleconaril (phenyl-d5, isoxazole-d3); VP 63843-d8; Picovir-d8
EINECS	Contact for details

Quality Control

Our Pleconaril-D8 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ¹³C) for structural confirmation and HPLC for chemical and isotopic purity assessment. A detailed Certificate of Analysis (COA) is provided, documenting purity, deuterium enrichment, and other critical specifications to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.