Description

Dapsone-D4 is a deuterated analog of the pharmaceutical compound dapsone, specifically labeled with four deuterium atoms. This stable isotope-labeled standard is essential for ensuring accuracy and reliability in quantitative analytical methods, particularly in complex biological matrices. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, clinical research, and forensic toxicology sectors who require precise internal standards for mass spectrometry.

Application

• Used as an internal standard for the accurate quantification of dapsone and its metabolites in biological samples via LC-MS/MS and GC-MS.
• Critical for pharmacokinetic and bioequivalence studies in drug development and clinical research.
• Enables precise analysis in therapeutic drug monitoring (TDM) for patients undergoing treatment for leprosy or dermatitis herpetiformis.
• Supports forensic and anti-doping analysis by providing a definitive reference to distinguish endogenous from exogenous substances.
• Facilitates metabolite identification and profiling studies in drug metabolism and disposition research.
• Employed in the development and validation of regulatory-compliant analytical methods for pharmaceutical quality control.

Basic Information

Product Name	Dapsone-D4
CAS No.	1346602-12-7
Molecular Formula	C12H8D4N2O2S
Molecular Weight	250.33 g/mol
Synonyms	4,4'-Sulfonylbis(2,3,5,6-tetradeuteroaniline); Dapsone-d4; Diaphenylsulfone-d4; Bis(4-amino-2,3,5,6-tetradeuterophenyl) sulfone; 4,4'-Diaminodiphenyl sulfone-d4; Avlosulfon-d4; DDS-d4
EINECS	Contact for details

Quality Control

Our Dapsone-D4 is manufactured under strict quality systems to ensure the highest isotopic purity and chemical integrity. Each batch is characterized by advanced spectroscopic techniques, including NMR and mass spectrometry, to confirm deuteration level and chemical purity. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically ≥98% D), chemical purity (by HPLC), and other critical parameters is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.