Description

Clevidipine-D5 is a deuterated isotopologue of the dihydropyridine calcium channel blocker, clevidipine, where five hydrogen atoms are replaced by deuterium. This stable-labeled compound is of critical importance as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and precision in pharmacokinetic and metabolism studies. It is an essential tool for pharmaceutical R&D laboratories and contract research organizations (CROs) engaged in the development and validation of LC-MS/MS assays for clevidipine.

Application

• Primary use as a stable isotope-labeled internal standard for the quantification of clevidipine in biological matrices via LC-MS/MS.
• Critical for method development and validation in bioanalytical laboratories to meet FDA and EMA guidelines.
• Enables accurate pharmacokinetic (PK) and toxicokinetic (TK) studies during drug development.
• Used in metabolite identification and profiling studies to understand drug metabolism pathways.
• Supports clinical trial research requiring precise measurement of clevidipine plasma concentrations.
• Essential for quality control and assurance in laboratories performing forensic or anti-doping analyses related to calcium channel blockers.

Basic Information

Item	Detail
Product Name	Clevidipine-D5
CAS No.	1346602-00-3
Molecular Formula	C21H18D5Cl2NO6
Molecular Weight	455.35 g/mol (approx.)
Synonyms	Butyroxymethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate-D5; Clevidipine-d5; Cleviprex-D5; H 324/38-D5; (RS)-Clevidipine-D5; 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl (3-oxobutyl) ester-D5; Stable Isotope of Clevidipine
EINECS	Contact for details

Quality Control

Every batch of Clevidipine-D5 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, confirmed by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and impurity profile is provided with each shipment to support your regulatory submissions and ensure data integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider storing under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.