Description

n-Desbutyl-n-Propyl Bumetanide-D5 is a high-purity, stable isotope-labeled analog of the loop diuretic bumetanide, specifically designed for use as an internal standard in quantitative analytical methods. This deuterated compound is essential for ensuring accuracy and precision in mass spectrometry-based assays, providing superior compensation for matrix effects and analyte loss during sample preparation. It is a critical material for pharmaceutical research, bioanalytical laboratories, and contract research organizations (CROs) engaged in pharmacokinetic studies, drug metabolism research, and clinical diagnostics.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the analysis of bumetanide and its metabolites in biological matrices (plasma, urine, serum).
• Pharmacokinetic & Bioequivalence Studies: Enables precise measurement of drug concentration-time profiles to support drug development, regulatory submissions, and bioequivalence assessments.
• Drug Metabolism and Disposition (DMPK): Used in studies investigating the absorption, distribution, metabolism, and excretion (ADME) of bumetanide.
• Clinical Research & Diagnostics: Supports the development and validation of robust clinical diagnostic assays for therapeutic drug monitoring (TDM).
• Forensic & Anti-Doping Analysis: Applicable in forensic toxicology and sports anti-doping control for the accurate quantification of bumetanide.
• Reference Material for Method Development: Serves as a certified reference material for developing, validating, and troubleshooting analytical methods in regulated laboratories.

Basic Information

Product Name	n-Desbutyl-n-Propyl Bumetanide-D5
CAS No.	1346601-70-4
Molecular Formula	C₁₇H₁₅D₅N₂O₅S
Molecular Weight	Approx. 367.43 g/mol
Synonyms	3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid-d5 (n-Desbutyl-n-Propyl); Bumetanide D5 (n-Desbutyl-n-Propyl); Bumetanide-d5 (n-Desbutyl-n-Propyl); Deuterated Bumetanide Internal Standard; Bumetanide-2H5 (n-Desbutyl-n-Propyl); [2H5]-Bumetanide (n-Desbutyl-n-Propyl); 3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid-d5 (n-Desbutyl-n-Propyl); Bumex-d5 (n-Desbutyl-n-Propyl analog)
EINECS	Contact for details

Quality Control

Our n-Desbutyl-n-Propyl Bumetanide-D5 is manufactured under strict quality control protocols to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay (by HPLC), isotopic purity (by MS), and identification. We adhere to cGMP principles where applicable, ensuring traceability and consistency for research and regulatory support.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, well-ventilated place. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (MS)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.