Description

Deschloro Bupropion-D9 Hydrochloride is a high-purity, deuterium-labeled internal standard critical for advanced analytical chemistry. This compound is essential for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and metabolic studies. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in method development and validation for bioanalytical assays.

Application

• Internal Standard for LC-MS/MS: Used as a stable, isotopically labeled reference compound for the precise quantification of bupropion and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical Research & Development: Facilitates accurate drug metabolism and pharmacokinetics (DMPK) studies, aiding in the understanding of absorption, distribution, metabolism, and excretion (ADME) profiles.
• Forensic and Clinical Toxicology: Enables reliable detection and measurement of bupropion levels in forensic analysis and therapeutic drug monitoring (TDM) programs.
• Method Development and Validation: Serves as a key component in developing and validating robust, sensitive, and specific analytical methods according to regulatory guidelines (e.g., FDA, EMA).
• Quality Control in Manufacturing: Supports impurity profiling and stability testing of active pharmaceutical ingredients (APIs) and finished drug products.
• Academic and Biomedical Research: Employed in university and institutional research projects focusing on neuropharmacology, antidepressant mechanisms, and substance analysis.

Basic Information

Product Name	Deschloro Bupropion-D9 Hydrochloride
CAS No.	1346601-65-7
Molecular Formula	C13H9D9ClNO • HCl
Molecular Weight	Contact for details
Synonyms	1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone-D9 Hydrochloride; (±)-2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-one-D9 Hydrochloride; Bupropion Deschloro-D9 HCl; Bupropion N-Deschloro-D9 Hydrochloride; Bupropion-d9 Metabolite Standard; Bupropion Impurity D9; Amfebutamone Deschloro-D9 Hydrochloride; Zyban-d9 Related Compound
EINECS	Contact for details

Quality Control

Our Deschloro Bupropion-D9 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and MS, to ensure high chemical and isotopic purity suitable for use as a certified reference material. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and chromatographic data is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.