Description

4-Methyl Erlotinib Hydrochloride is a high-purity, small-molecule pharmaceutical intermediate and reference standard. This compound is critical for research and development in the field of targeted cancer therapies, specifically as a structural analog for kinase inhibitor studies. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) for analytical and synthetic applications.

Application

• Pharmaceutical Intermediate: Key building block in the research-scale synthesis of novel Erlotinib analogs and tyrosine kinase inhibitors.
• Reference Standard: Used for analytical method development, validation, and quality control (HPLC, LC-MS) in API manufacturing.
• Biochemical Research: Serves as a tool compound in pharmacological studies to investigate structure-activity relationships (SAR) of EGFR inhibitors.
• Process Development: Employed in route scouting and optimization for the production of related therapeutic candidates.
• Impurity Standard: Essential for identifying and quantifying potential process-related impurities in Erlotinib API batches.

Basic Information

Product Name	4-Methyl Erlotinib Hydrochloride
CAS No.	1346601-52-2
Molecular Formula	C23H24ClN3O4
Molecular Weight	441.91 g/mol
Synonyms	N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-methylquinazolin-4-amine hydrochloride; 4-Methyl Erlotinib HCl; 4-Methyl-N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride; Erlotinib 4-Methyl Analog Hydrochloride; Tarceva 4-Methyl Derivative HCl; CP-358774 4-Methyl Derivative Hydrochloride; OSI-774 4-Methyl Analog HCl
EINECS	Contact for details

Quality Control

Our 4-Methyl Erlotinib Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all test results against predefined specifications to ensure consistency and traceability for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.