Description

1-Hydroxy Valdecoxib-13C2,15N is a stable isotope-labeled analog of a key valdecoxib metabolite, specifically designed for use as an internal standard in quantitative bioanalytical studies. This compound is critical for ensuring the accuracy and reliability of mass spectrometry-based assays by correcting for variations in sample preparation and instrument response. It is an essential tool for pharmaceutical researchers, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioequivalence testing, and forensic toxicology.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in LC-MS/MS and GC-MS methods for the precise quantification of valdecoxib and its metabolites in biological matrices such as plasma, serum, and urine.
• Drug Metabolism & Pharmacokinetics (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Biomarker Research: Used in the development and validation of assays for metabolic pathway analysis and biomarker discovery related to cyclooxygenase-2 (COX-2) inhibition.
• Forensic and Clinical Toxicology: Supports the accurate detection and measurement of valdecoxib in cases of overdose or for therapeutic drug monitoring.
• Pharmaceutical Quality Control: Can be utilized in impurity profiling and stability studies of pharmaceutical formulations containing valdecoxib.
• Reference Standard: Acts as a high-purity certified reference material (CRM) for method development and calibration in analytical laboratories.

Basic Information

Product Name	1-Hydroxy Valdecoxib-13C2,15N
CAS No.	1346601-29-3
Molecular Formula	C1513C2H13N15NO3S
Molecular Weight	~318.34 g/mol (for 13C2, 15N labeled form)
Synonyms	1-Hydroxy Valdecoxib-13C2,15N; Valdecoxib Hydroxy Metabolite-13C2,15N; 4-[5-Methyl-3-phenyl-4-isoxazolyl]benzenesulfonamide-1-hydroxy-13C2,15N; 1-Hydroxy-4-(5-methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide-13C2,15N; Isotopically Labeled Valdecoxib Metabolite; BEXTRA Metabolite-13C2,15N; SC 65872-13C2,15N (Hydroxy)
EINECS	Contact for details

Quality Control

Every batch of 1-Hydroxy Valdecoxib-13C2,15N is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, confirmed by advanced spectroscopic and chromatographic techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific data for identity, purity (HPLC), isotopic enrichment, and residual solvents. Our quality commitment ensures the material meets the stringent requirements for use as a certified reference standard in regulated bioanalytical laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C; ≥ 99 atom % 15N
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.