Description

Rac N,n-Didesmethyl-n-(4-Hydroxyphenethyl)-o-Desmethyl Venlafaxine is a key advanced pharmaceutical intermediate and a metabolite of the antidepressant venlafaxine. This compound is of significant value for research and development in neuropharmacology and for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers specializing in the production of high-purity reference standards and metabolites for analytical and synthetic applications.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for analytical method development and validation in bioanalytical studies.
• Metabolite Research: Critical for in-vitro and in-vivo metabolism studies of venlafaxine, aiding in pharmacokinetic and pharmacodynamic profiling.
• Active Pharmaceutical Ingredient (API) Synthesis: Used as a sophisticated building block in the synthetic pathways for novel serotonin-norepinephrine reuptake inhibitors (SNRIs) and related compounds.
• Biochemical Research: Employed in studies investigating neurotransmitter reuptake mechanisms and receptor binding assays.
• Impurity Standard: Acts as a known impurity or degradation product standard for quality control testing of venlafaxine and its pharmaceutical formulations.
• Preclinical Development: Utilized in the early-stage development of new chemical entities (NCEs) targeting the central nervous system.

Basic Information

Product Name	Rac N,n-Didesmethyl-n-(4-Hydroxyphenethyl)-o-Desmethyl Venlafaxine
CAS No.	1346601-21-5
Molecular Formula	C17H21NO2
Molecular Weight	271.36 g/mol
Synonyms	O-Desmethylvenlafaxine N,N-didesmethyl metabolite; 1-[2-(Dimethylamino)-1-(4-hydroxyphenyl)ethyl]cyclohexanol; N,N-Didesmethyl-O-desmethylvenlafaxine; rac-Venlafaxine metabolite; DDV; Cyclohexanol, 1-[2-(dimethylamino)-1-(4-hydroxyphenyl)ethyl]-; 1-(4-Hydroxyphenyl)-2-(dimethylamino)-1-cyclohexylethanol
EINECS	Contact for details

Quality Control

Our Rac N,n-Didesmethyl-n-(4-Hydroxyphenethyl)-o-Desmethyl Venlafaxine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.