Description

α-Desmethyl Anastrozole-D3 is a deuterium-labeled internal standard critical for precise quantitative analysis in mass spectrometry. This high-purity compound is essential for ensuring accuracy and reliability in bioanalytical method development and validation. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities specializing in pharmacokinetics, metabolism studies, and drug impurity profiling.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the accurate quantification of anastrozole and its metabolites in biological matrices like plasma and serum.
• Drug Metabolism and Pharmacokinetics (DMPK): Facilitates stable isotope dilution assays to study the absorption, distribution, metabolism, and excretion (ADME) profile of anastrozole.
• Bioanalytical Method Validation: Critical for developing and validating robust, sensitive, and specific HPLC-MS/MS methods in compliance with FDA and ICH guidelines.
• Clinical Research: Supports therapeutic drug monitoring and clinical trial sample analysis for the aromatase inhibitor anastrozole.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of desmethyl metabolite impurities in active pharmaceutical ingredient (API) batches.
• Forensic and Anti-Doping Analysis: Employed in confirmatory testing protocols where precise measurement of anastrozole is required.

Basic Information

Product Name	α-Desmethyl Anastrozole-D3
CAS No.	1346601-01-1
Molecular Formula	C16H14D3N5
Molecular Weight	278.36 g/mol
Synonyms	2,2'-[5-(1H-1,2,4-Triazol-1-ylmethyl)-1,3-phenylene]bis(2-methylpropiononitrile)-d3; Anastrozole Desmethyl Metabolite D3; 1,3-Bis(2-cyano-2-propyl)-5-((1H-1,2,4-triazol-1-yl)methyl)benzene-d3; Desmethylanastrozole-d3; Anastrozole-d3 Metabolite; [D3]-α-Desmethyl Anastrozole; Deuterated Anastrozole Internal Standard
EINECS	Contact for details

Quality Control

Every batch of α-Desmethyl Anastrozole-D3 is manufactured and controlled under strict quality management systems. We provide comprehensive analytical data to support its use in regulated environments. The product typically meets specifications for chemical purity (≥95% by HPLC) and isotopic enrichment (≥98 atom % D). A detailed Certificate of Analysis (COA) containing results for identity, purity, assay, and residual solvents is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). This material is hygroscopic (moisture-sensitive). The container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity (Atom % D)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.