Description

o-Desisopropyl-o-Methyl Bisoprolol-D7 Hemifumarate is a high-purity, deuterium-labeled (D7) internal standard critical for accurate quantitative analysis in bioanalytical and pharmacokinetic studies. This compound is specifically designed for use in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) to ensure precise measurement of bisoprolol and its metabolites in complex biological matrices. It is an essential tool for pharmaceutical R&D, clinical research, and forensic toxicology laboratories requiring the highest standards of analytical reliability and data integrity.

Application

• LC-MS/MS Internal Standard: Primary application as a deuterated internal standard for the precise quantification of bisoprolol in plasma, serum, and urine samples.
• Pharmacokinetic & Bioequivalence Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical trials.
• Metabolite Profiling: Used in research to identify and quantify the metabolic pathways and degradation products of bisoprolol.
• Forensic & Doping Analysis: Supports reliable detection and confirmation of bisoprolol in forensic investigations and anti-doping controls.
• Pharmaceutical Quality Control: Serves as a reference standard in the quality assurance of bisoprolol active pharmaceutical ingredients (APIs) and finished dosage forms.
• Regulatory Submissions: Provides the validated data required for regulatory filings with agencies like the FDA and EMA.

Basic Information

Product Name	o-Desisopropyl-o-Methyl Bisoprolol-D7 Hemifumarate
CAS No.	1346600-98-3
Molecular Formula	C20H28D7NO5 • 0.5C4H4O4
Molecular Weight	~ 418.6 g/mol (as hemifumarate salt)
Synonyms	Bisoprolol D7 Metabolite; Bisoprolol-d7 Desisopropyl Methyl Metabolite; 1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol-d7 Hemifumarate; Deuterated Bisoprolol Acid Metabolite; Bisoprolol Acid-D7; (RS)-1-(4-((2-Isopropoxyethoxy)methyl)phenoxy)-3-(isopropylamino)propan-2-ol-d7 Hemifumarate; Internal Standard for Bisoprolol LC-MS
EINECS	Contact for details

Quality Control

Every batch of o-Desisopropyl-o-Methyl Bisoprolol-D7 Hemifumarate is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment. Our quality assurance protocol is designed to meet the stringent requirements of analytical reference standard applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications for isotopic purity, chemical purity, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D7)	≥ 98.0 atom % D
Chemical Purity (HPLC)	≥ 95.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.