Description

n-Dechloroethyl Cyclophosphamide-D4 is a deuterium-labeled analog of a key cyclophosphamide metabolite, serving as a critical internal standard for precise quantitative analysis. This high-purity reference material is essential for ensuring accuracy and reliability in sensitive analytical methods, particularly in regulated environments. It is primarily needed by pharmaceutical research laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism, pharmacokinetic (DMPK) studies, and bioanalytical method development.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the quantification of cyclophosphamide and its metabolites in biological matrices.
• Critical component in bioanalytical method development and validation for clinical and preclinical studies.
• Supporting drug metabolism and pharmacokinetics (DMPK) research to understand the disposition of cyclophosphamide.
• Use in forensic and anti-doping analysis for the accurate detection of cyclophosphamide.
• Quality control and reference standard in pharmaceutical manufacturing of cyclophosphamide-based therapies.
• Tool for environmental monitoring studies tracking pharmaceutical residues.

Basic Information

Item	Details
Product Name	n-Dechloroethyl Cyclophosphamide-D4
CAS No.	1346600-68-7
Molecular Formula	C7H11D4Cl2N2O2P
Molecular Weight	Contact for details
Synonyms	2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide-D4; Cyclophosphamide Monohydrate D4 Metabolite; 4-Hydroxycyclophosphamide-D4; Deuterated Cyclophosphamide Metabolite; Nor-N-dechloroethyl Cyclophosphamide-D4; Perdeuterated Cyclophosphamide Derivative; N-Dechloroethyl Cyclophosphamide (d4)
EINECS	Contact for details

Quality Control

Our n-Dechloroethyl Cyclophosphamide-D4 is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for analytical reference standards. Each batch is characterized using advanced spectroscopic and chromatographic techniques, including NMR and HPLC-MS, to confirm identity, chemical purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided to guarantee traceability and compliance with your research or quality control protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified and stored in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chemical Purity (by HPLC)	≥ 95.0%
Deuterium Incorporation (D-enrichment)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.