Description

Aripiprazole-D8 N4-Oxide is a deuterated and oxidized derivative of the antipsychotic drug aripiprazole, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in complex biological matrices. It is an essential tool for pharmaceutical research and development, clinical laboratories, and regulatory agencies involved in drug metabolism and pharmacokinetic (DMPK) studies, bioequivalence testing, and therapeutic drug monitoring.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, isotopically labeled internal standard for the precise quantification of aripiprazole and its metabolites in bioanalytical methods.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetic (DMPK) studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of aripiprazole.
• Clinical Research: Enables accurate therapeutic drug monitoring (TDM) in patient plasma or serum samples to optimize dosing regimens.
• Bioequivalence Studies: Critical for validating analytical methods in studies comparing generic and brand-name formulations of aripiprazole.
• Forensic Toxicology: Supports the accurate identification and quantification of aripiprazole in forensic casework.
• Metabolite Profiling: Aids in the structural elucidation and quantification of N-oxide metabolites of aripiprazole.

Basic Information

Product Name	Aripiprazole-D8 N4-Oxide
CAS No.	1346600-39-2
Molecular Formula	C23H19D8Cl2N3O3
Molecular Weight	466.42 g/mol
Synonyms	7-{4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy}-3,4-dihydro-2(1H)-quinolinone-D8 N4-Oxide; Aripiprazole D8 N-Oxide; Aripiprazole-d8 N-Oxide; Deuterated Aripiprazole N-Oxide; Aripiprazole N-Oxide-d8; Abilify-d8 N-Oxide
EINECS	Contact for details

Quality Control

Every batch of Aripiprazole-D8 N4-Oxide is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and stability. Our products are characterized using advanced techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for purity, isotopic enrichment, and impurities is provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.