Description

Aripiprazole-D8 N1-Oxide is a deuterated and oxidized derivative of the antipsychotic drug aripiprazole, specifically labeled with eight deuterium atoms. This compound is of critical importance as a high-purity reference standard and an advanced intermediate in pharmaceutical research and development. It is primarily needed by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in metabolite identification, quantitative bioanalysis, and drug metabolism and pharmacokinetics (DMPK) studies.

Application

• Internal Standard for LC-MS/MS: Serves as a stable isotope-labeled internal standard for the precise quantification of aripiprazole and its metabolites in biological matrices, enhancing analytical accuracy and reproducibility.
• Metabolite Reference Material: Used as an authentic reference standard for the identification and characterization of the N1-oxide metabolite of aripiprazole in in vitro and in vivo studies.
• Pharmaceutical Impurity Profiling: Employed in the development and validation of analytical methods to monitor and control process-related impurities and degradation products.
• DMPK and Toxicology Research: Facilitates studies on the absorption, distribution, metabolism, and excretion (ADME) pathways of aripiprazole, supporting safety and efficacy assessments.
• Stable Isotope Labeling Studies: Acts as a key intermediate in the synthesis of more complex deuterated analogs for advanced tracer studies.

Basic Information

Item	Detail
Product Name	Aripiprazole-D8 N1-Oxide
CAS No.	1346600-34-7
Molecular Formula	C23H19D8Cl2N3O3
Molecular Weight	466.42 g/mol (approx.)
Synonyms	7-{4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy}-3,4-dihydro-2(1H)-quinolinone-D8 N1-Oxide; Aripiprazole D8 N-Oxide; OPC-14597-D8 N1-Oxide; Abilify-D8 N1-Oxide; Deuterated Aripiprazole N-Oxide; Aripiprazole (D8) N-Oxide; Aripiprazole N-Oxide-d8
EINECS	Contact for details

Quality Control

Our Aripiprazole-D8 N1-Oxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and mass spectrometry, to confirm structural identity, isotopic purity (D-enrichment), and chemical purity. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring traceability and compliance with research-grade standards. Our quality commitment supports reliable and reproducible results in your critical analytical workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.