Description

o-Desisopropyl-o-Ethyl Bisoprolol-D7 Hemifumarate is a high-purity, deuterated analog of the active pharmaceutical ingredient Bisoprolol, specifically designed for use as an internal standard in quantitative analytical methods. This compound is critical for ensuring accuracy and reliability in pharmacokinetic, metabolic, and bioanalytical studies within pharmaceutical research and development. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in method development, validation, and quality control.

Application

• Internal Standard for LC-MS/MS Analysis: Essential for the precise quantification of Bisoprolol and its metabolites in biological matrices such as plasma, serum, and urine.
• Pharmaceutical R&D: Supports method development and validation studies for new drug formulations containing Bisoprolol.
• Bioequivalence and Pharmacokinetic Studies: Enables accurate measurement of drug concentration over time in clinical trials.
• Metabolite Identification and Profiling: Aids in the detection and structural elucidation of drug metabolites using mass spectrometry.
• Quality Control in Manufacturing: Used in analytical laboratories to monitor the purity and consistency of Bisoprolol active pharmaceutical ingredient (API) and finished dosage forms.
• Forensic and Doping Control Analysis: Applied in specialized testing for the detection of β-blockers in forensic toxicology and anti-doping programs.

Basic Information

Item	Detail
Product Name	o-Desisopropyl-o-Ethyl Bisoprolol-D7 Hemifumarate
CAS No.	1346600-13-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Bisoprolol D7 Hemifumarate; Bisoprolol-d7 Hemifumarate; 1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol-d7 Hemifumarate; Deuterated Bisoprolol Hemifumarate; Bisoprolol Internal Standard; (RS)-1-(4-((2-Isopropoxyethoxy)methyl)phenoxy)-3-(isopropylamino)propan-2-ol-d7 Hemifumarate
EINECS	Contact for details

Quality Control

Our o-Desisopropyl-o-Ethyl Bisoprolol-D7 Hemifumarate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and mass spectrometry, to confirm identity, chemical purity, and isotopic enrichment. Certificates of Analysis (COA) detailing all test results are provided to ensure full traceability and compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.