Description

Rac Deoxy-o-Desmethyl Venlafaxine-D6 CAS NO 1346600-06-3 is a deuterated isotopologue of a key metabolite of the antidepressant venlafaxine, serving as a critical internal standard for precise analytical quantification. This high-purity reference material is essential for ensuring accuracy and reliability in bioanalytical studies and pharmaceutical research. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism and pharmacokinetics (DMPK) studies, therapeutic drug monitoring, and forensic toxicology.

Application

• Internal Standard for LC-MS/MS Analysis: Used as a stable isotope-labeled internal standard for the accurate quantification of venlafaxine and its metabolites in biological matrices like plasma, serum, and urine.
• Pharmaceutical Research & Development: Supports method development and validation in DMPK studies during drug discovery and development phases.
• Clinical Toxicology and Forensic Analysis: Enables precise measurement of drug concentrations for therapeutic drug monitoring, overdose cases, and forensic investigations.
• Metabolite Identification and Characterization: Aids in the structural elucidation and study of metabolic pathways of venlafaxine.
• Quality Control in Reference Material Production: Serves as a calibrant or system suitability check for ensuring the quality of other analytical reference standards.
• Regulatory Compliance Testing: Facilitates testing that adheres to guidelines from agencies like the FDA and EMA for bioanalytical method validation.

Basic Information

Product Name	Rac Deoxy-o-Desmethyl Venlafaxine-D6
CAS No.	1346600-06-3
Molecular Formula	C16H19D6NO2
Molecular Weight	269.42 g/mol
Synonyms	O-Desmethylvenlafaxine-d6; Desvenlafaxine-d6; Didesmethylvenlafaxine-d6; rac-1-[2-(Dimethylamino)-1-(4-hydroxyphenyl)ethyl]cyclohexanol-d6; 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol-d6; ODV-d6; WY-45233-d6
EINECS	Contact for details

Quality Control

Every batch of our Rac Deoxy-o-Desmethyl Venlafaxine-D6 is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity, verified by advanced techniques including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and isotopic enrichment is supplied with each product to support your compliance and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.