Description

Diethyl Rivastigmine-D10 is a deuterium-labeled analog of the active pharmaceutical ingredient rivastigmine, a cholinesterase inhibitor. This high-purity reference standard is critical for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly in pharmacokinetic and metabolism studies. It is an essential material for pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory bodies requiring precise internal standards for mass spectrometry.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and LC-MS/MS bioanalysis.
• Quantification of rivastigmine and its metabolites in pharmacokinetic (PK) and bioavailability studies.
• Method development and validation for drug monitoring in clinical research and forensic toxicology.
• Quality control and assurance in the manufacturing of rivastigmine-based pharmaceutical products.
• Use in deuterium labeling studies and metabolic pathway elucidation.
• Reference material for regulatory submissions to agencies like the FDA and EMA.

Basic Information

Product Name	Diethyl Rivastigmine-D10
CAS No.	1346599-05-0
Molecular Formula	C14H12D10N2O2
Molecular Weight	256.38 g/mol
Synonyms	(S)-3-[1-(Dimethylamino)ethyl]phenyl ethyl(methyl)carbamate-d10; Rivastigmine-d10; Exelon-d10; SDZ ENA 713-d10; Deuterated Rivastigmine; Rivastigmine (ethyl-d5, methyl-d5); N-Ethyl-N-methylcarbamic acid (S)-3-[1-(dimethylamino)ethyl]phenyl ester-d10
EINECS	Contact for details

Quality Control

Every batch of Diethyl Rivastigmine-D10 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support its use as a certified reference material. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing isotopic purity, chemical purity, and chromatographic data.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or desiccated conditions after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.