Description

n-(4-Methoxy-3,5-Dimethyl-2-Pyridinyl)Methyl Omeprazole-D3 Sulfide is a deuterated isotopologue of an omeprazole sulfide derivative, serving as a critical stable isotope-labeled intermediate in pharmaceutical research and development. This compound is essential for creating internal standards used in mass spectrometry, enabling highly accurate and sensitive quantification of omeprazole and its metabolites in complex biological matrices. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and clinical trial support.

Application

• Internal Standard for LC-MS/MS: Acts as a stable, non-interfering reference compound for the precise quantification of omeprazole and related sulfide metabolites in plasma, serum, and other biological samples.
• Drug Metabolism Studies (DMPK): Facilitates the tracking and analysis of metabolic pathways, absorption, distribution, and excretion profiles of proton pump inhibitor drugs.
• Bioanalytical Method Development: Used to validate and optimize high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) assays for regulatory compliance.
• Clinical Pharmacology Research: Supports studies investigating drug-drug interactions, bioavailability, and therapeutic drug monitoring for gastroesophageal reflux disease (GERD) and ulcer treatments.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradation products during drug substance manufacturing.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in this gold-standard technique to achieve the highest level of analytical accuracy and traceability in quantitative analysis.

Basic Information

Product Name	n-(4-Methoxy-3,5-Dimethyl-2-Pyridinyl)Methyl Omeprazole-D3 Sulfide
CAS No.	1346598-97-7
Molecular Formula	C₁₇H₁₉D₃N₃O₃S
Molecular Weight	345.46 g/mol
Synonyms	Omeprazole Sulfide-d3; 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole-d3 Sulfide; 5-Methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfanyl}-1H-1,3-benzodiazole-d3; Deuterated Omeprazole Sulfide Intermediate; Omeprazole-d3 Sulfide Derivative; (RS)-Omeprazole Sulfide-d3; 2-(((4-Methoxy-3,5-dimethylpyridin-2-yl)methyl)thio)-5-methoxy-1H-benzo[d]imidazole-d3
EINECS	Contact for details

Quality Control

Every batch of n-(4-Methoxy-3,5-Dimethyl-2-Pyridinyl)Methyl Omeprazole-D3 Sulfide is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high chemical purity, isotopic enrichment, and structural integrity. Our quality assurance protocols are designed to meet the stringent requirements of pharmaceutical R&D and bioanalysis. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), isotopic purity (by MS), identity (by IR, NMR), and other critical parameters is provided with each shipment to guarantee traceability and compliance with your research standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 99.0 atom % D
Chemical Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.