Description

Dimenhydrinate-D12 is a deuterium-labeled internal standard of the well-known antiemetic and antihistaminic drug, dimenhydrinate, specifically designed for analytical applications. This high-purity compound is essential for ensuring accuracy and reliability in quantitative mass spectrometry, providing a stable isotopic reference for precise measurement. It is a critical reagent for pharmaceutical research, clinical laboratories, and forensic toxicology departments engaged in method development, pharmacokinetic studies, and drug metabolism research.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a stable isotope-labeled internal standard for the accurate quantification of dimenhydrinate and its metabolites in complex biological matrices.
• Pharmacokinetic and Bioavailability Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Metabolism Research: Used to identify and quantify metabolite profiles, aiding in the understanding of metabolic pathways and potential drug-drug interactions.
• Forensic and Clinical Toxicology: Provides a reliable reference for the confirmatory analysis of dimenhydrinate in cases of overdose, poisoning, or driving under the influence investigations.
• Pharmaceutical Quality Control: Supports the development and validation of robust analytical methods for the assay and impurity profiling of dimenhydrinate in active pharmaceutical ingredients (APIs) and finished dosage forms.
• Regulatory Compliance and Method Validation: Essential for meeting stringent regulatory requirements (e.g., FDA, EMA) for bioanalytical method validation, ensuring data integrity and reproducibility.

Basic Information

Product Name	Dimenhydrinate-D12
CAS No.	1346598-96-6
Molecular Formula	C24H20D12ClN5O3
Molecular Weight	470.04 g/mol (for D12 labeled form)
Synonyms	Dimenhydrinate-d12; 8-Chlorotheophylline-d12 Diphenhydramine-d12 Salt; 2-(Benzhydryloxy)-N,N-dimethylethylamine 8-chlorotheophyllinate-d12; Dramamine-d12; 1H-Purine-2,6-dione, 8-chloro-3,7-dihydro-1,3-dimethyl-, compd. with 2-(diphenylmethoxy)-N,N-dimethylethanamine-d12 (1:1); Deuterated Dimenhydrinate; Dimenhydrinate (phenyl-d12)
EINECS	Contact for details

Quality Control

Our Dimenhydrinate-D12 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, isotopic enrichment (typically ≥98% D), and chemical purity. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to expected mass spectrum
Purity (HPLC)	≥ 98.0% (chemical purity)
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.