Description

m-Isobutyl Ibuprofen-D3 is a deuterated isotopologue of a key ibuprofen derivative, specifically labeled on the isobutyl side chain. This compound is of significant value as a stable isotope-labeled internal standard for precise analytical quantification in complex matrices. It is primarily required by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical testing facilities engaged in method development, pharmacokinetic studies, and quality control for ibuprofen-related compounds.

Application

• Internal Standard for LC-MS/MS Analysis: Essential for accurate quantification of ibuprofen and its metabolites in bioanalytical studies (plasma, serum, urine).
• Pharmaceutical R&D: Used in method development and validation for drug substance and drug product testing to ensure specificity and accuracy.
• Metabolite Tracing and Pharmacokinetics: Enables detailed studies on drug absorption, distribution, metabolism, and excretion (ADME) due to its isotopic stability.
• Quality Control & Assurance: Serves as a critical reference standard in quality control laboratories to verify assay precision and monitor for impurities.
• Forensic and Doping Control Analysis: Provides reliable quantification in forensic toxicology and anti-doping programs where precise measurement is legally critical.

Basic Information

Product Name	m-Isobutyl Ibuprofen-D3
CAS No.	1346598-90-0
Molecular Formula	C13H15D3O2
Molecular Weight	209.30 g/mol (approx.)
Synonyms	2-[4-(2-Methylpropyl)phenyl]propanoic-3,3,3-d3 acid; Ibuprofen-d3 (isobutyl-d3); α-Methyl-4-(isobutyl-d3)benzeneacetic acid; 4-Isobutyl-d3-α-methylphenylacetic acid; Deuteronated Ibuprofen (side chain); Ibuprofen Internal Standard-d3; IBP-d3; [2H3]-Ibuprofen
EINECS	Contact for details

Quality Control

Our m-Isobutyl Ibuprofen-D3 is manufactured under strict quality systems to ensure high chemical and isotopic purity suitable for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay (by HPLC), isotopic enrichment (by NMR or MS), and related substance profiles. We adhere to relevant industry standards for reference materials, and custom purity grades or certifications (e.g., for GMP use) can be discussed.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to expected mass spectrum
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.