Description

Des[2-(2-Thienylmethyl)] Eprosartan-2-Carboxylic Acid-13C3 is a stable isotope-labeled analog of a key eprosartan intermediate, where three carbon atoms are replaced with the 13C isotope. This compound is essential for use as an internal standard in quantitative bioanalytical methods, providing unmatched accuracy and reliability for pharmacokinetic and metabolic studies. It is a critical material for pharmaceutical R&D laboratories and CROs specializing in LC-MS/MS method development for angiotensin II receptor antagonist drugs.

Application

• Internal Standard for LC-MS/MS Analysis: Primary application as a high-purity, isotopically labeled internal standard for the precise quantification of eprosartan and related metabolites in biological matrices (plasma, serum, urine).
• Pharmaceutical R&D and Metabolism Studies: Enables accurate pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) profiling during drug development.
• Bioequivalence and Clinical Trial Support: Critical for ensuring data integrity in bioanalytical assays supporting clinical trials and generic drug development.
• Method Development and Validation: Used by analytical scientists to develop, optimize, and validate robust quantitative mass spectrometry methods.
• Reference Material for Impurity Characterization: Serves as a reference compound for identifying and characterizing process-related impurities or degradation products in active pharmaceutical ingredient (API) batches.

Basic Information

Product Name	Des[2-(2-Thienylmethyl)] Eprosartan-2-Carboxylic Acid-13C3
CAS No.	1346598-85-3
Molecular Formula	C22H2213C3N2O4S
Molecular Weight	~ 425.5 g/mol (for 13C3 labeled form)
Synonyms	Eprosartan-2-Carboxylic Acid-13C3 Des-Thienylmethyl Derivative; (E)-3-[2-Carboxy-2-(thiophen-2-ylmethyl)prop-1-enyl]-2-13C-2-butyl-4-chloro-1-13C-13C-methyl-1H-imidazole-5-carboxylic Acid; Isotopically Labeled Eprosartan Intermediate; 13C3-Labeled Eprosartan Carboxylic Acid Derivative; AT1 Receptor Antagonist Intermediate-13C3; SK&F 108566-13C3 Derivative
EINECS	Contact for details

Quality Control

Every batch of Des[2-(2-Thienylmethyl)] Eprosartan-2-Carboxylic Acid-13C3 is manufactured and controlled under a strict quality management system. We guarantee high chemical and isotopic purity to ensure optimal performance as an internal standard. Comprehensive testing includes identity confirmation, assay by HPLC, determination of isotopic enrichment (13C), and control of related substances. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C (at labeled positions)
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.